Schizophrenia & CBD

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.

Posted by Joe Pavlik on

Published: Transl Psychiatry. 2012 Mar 20;2:e94. doi: 10.1038/tp.2012.15. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J, Hellmich M, Koethe D. Abstract Cannabidiol is a component of marijuana that does not activate cannabinoid receptors, but moderately inhibits the degradation of the endocannabinoid anandamide. We previously reported that an elevation of anandamide levels in cerebrospinal fluid inversely correlated to psychotic symptoms. Furthermore, enhanced anandamide signaling let to a lower transition rate from initial prodromal states into frank psychosis as well as postponed transition. In our translational approach,...

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