Huntington's Disease & CBD
Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington's disease.
Posted by Joe Pavlik on
Published: Neuropharmacology. 2015 Feb;89:368-74. doi: 10.1016/j.neuropharm.2014.07.021. Epub 2014 Aug 11. Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington's disease. Pietropaolo S, Bellocchio L, Ruiz-Calvo A, Cabanas M, Du Z, Guzmán M, Garret M, Cho YH. Abstract Huntington's disease (HD) is a devastating neurodegenerative disease characterized by a progressive decline in motor abilities, as well as in cognitive and social behaviors. Most of these behavioral deficits are recapitulated in the R6/1 transgenic mouse, which can therefore be used as an experimental model to identify the neurobiological substrates of HD pathology and to design novel therapeutic...