CBD as an Anti-Depressant

Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa

Posted by Joe Pavlik on

Published: CNS & neurological disorders drug targets 13(6):953-60. August 2014 Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa Alexandre Rafael de Mello Schier, Natalia Pinho de Oliveira Ribeiro, Danielle Sousa Coutinho, Adriana Cardoso Abstract Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non- psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this work is to review the animal study articles using CBD as an anxiolytic-like and antidepressant-like compound. Articles...

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Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/ glutamate neurotransmission: role of 5-HT1A receptors

Posted by Joe Pavlik on

Published: Neuropharmacology, Volume 103, April 2016, Pages 16–26 Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/ glutamate neurotransmission: role of 5-HT1A receptors Raquel Lingea, Laura Jiménez-Sánchezb, Leticia Campab, Fuencisla Pilar-Cuéllara, Rebeca Vidala, Angel Pazosa, Albert Adella, Álvaro Díaza, b, Abstract Cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic- like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD following acute and chronic administration in the olfactory bulbectomy mouse model of depression (OBX), and investigated...

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