CBD as a Neuro-Protectant

Cannabinoids and neuroprotection in motor-related disorders.

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Published: CNS Neurol Disord Drug Targets. 2007 Dec;6(6):377-87. Cannabinoids and neuroprotection in motor-related disorders. de Lago E, Fernández-Ruiz J. Abstract Neuroprotective properties of cannabinoids have been extensively studied in the last years in different neurodegenerative pathologies. This potential is based on the antioxidant, anti- inflammatory and anti-excitotoxic properties exhibited by these compounds that allow them to afford neuroprotection in different neurodegenerative disorders like Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS) and others. PD and HD are chronic pathologies that are caused by the degeneration of specific structures within the basal ganglia. In both disorders, the key mechanisms involved in...

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Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

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Published: Br J Clin Pharmacol. 2013 Feb;75(2):323-33. doi: 10.1111/j.1365-2125.2012.04341.x. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? Fernández-Ruiz J, Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez- Orgado J. Abstract Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders exerted through molecular mechanisms that are yet to be completely identified. CBD acts in some experimental models as an anti-inflammatory, anticonvulsant, anti-oxidant, anti-emetic, anxiolytic and antipsychotic agent, and is therefore a potential medicine for the treatment of neuroinflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia, respectively. The neuroprotective potential of CBD, based...

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The effectiveness of cannabinoids in the management of chronic nonmalignant neuropathic pain: a systematic review.

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Published: J Oral Facial Pain Headache. 2015 Winter;29(1):7-14. doi: 10.11607/ofph.1274. The effectiveness of cannabinoids in the management of chronic nonmalignant neuropathic pain: a systematic review. Boychuk DG, Goddard G, Mauro G, Orellana MF. Abstract AIMS: To carry out a systematic review to assess the effectiveness of cannabis extracts and cannabinoids in the management of chronic nonmalignant neuropathic pain. METHODS: Electronic database searches were performed using Medline, PubMed, Embase, all evidence- based medicine reviews, and Web of Science, through communication with the Canadian Consortium for the Investigation of Cannabinoids (CCIC), and by searching printed indices from 1950. Terms used were marijuana, marihuana,...

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Cannabidiol Normalizes Caspase 3, Synaptophysin, and Mitochondrial Fission Protein DNM1L Expression Levels in Rats with Brain Iron Overload: Implications for Neuroprotection

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Published: Mol Neurobiol (2014) 49: 222. doi: 10.1007/s12035-013-8514-7 da Silva, V.K., de Freitas, B.S., da Silva Dornelles, A. et al. Cannabidiol Normalizes Caspase 3, Synaptophysin, and Mitochondrial Fission Protein DNM1L Expression Levels in Rats with Brain Iron Overload: Implications for Neuroprotection Vanessa Kappel da SilvaBetânia Souza de FreitasArethuza da Silva DornellesLaura Roesler NeryLucio FalavignaRafael Dal Ponte FerreiraMaurício Reis BogoJaime Eduardo Cecílio HallakAntônio Waldo ZuardiJosé Alexandre S. CrippaNadja Schröder Abstract We have recently shown that chronic treatment with cannabidiol (CBD) was able to recover memory deficits induced by brain iron loading in a dose-dependent manner in rats. Brain iron accumulation is implicated in...

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Cannabidiol Normalizes Caspase 3, Synaptophysin, and Mitochondrial Fission Protein DNM1L Expression Levels in Rats with Brain Iron Overload: Implications for Neuroprotection

Posted by Joe Pavlik on

Published: Mol Neurobiol (2014) 49: 222. doi: 10.1007/s12035-013-8514-7 da Silva, V.K., de Freitas, B.S., da Silva Dornelles, A. et al. Cannabidiol Normalizes Caspase 3, Synaptophysin, and Mitochondrial Fission Protein DNM1L Expression Levels in Rats with Brain Iron Overload: Implications for Neuroprotection Vanessa Kappel da SilvaBetânia Souza de FreitasArethuza da Silva DornellesLaura Roesler NeryLucio FalavignaRafael Dal Ponte FerreiraMaurício Reis BogoJaime Eduardo Cecílio HallakAntônio Waldo ZuardiJosé Alexandre S. CrippaNadja Schröder Abstract We have recently shown that chronic treatment with cannabidiol (CBD) was able to recover memory deficits induced by brain iron loading in a dose-dependent manner in rats. Brain iron accumulation is implicated...

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