Cannabinoids, Chronic Neuropathic Pain & CBD

Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes.

Posted by Joe Pavlik on

Published: Curr Neuropharmacol. 2006 Jul;4(3):239-57. Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes. Manzanares J, Julian M, Carrascosa A. Abstract Cannabis extracts and synthetic cannabinoids are still widely considered illegal substances. Preclinical and clinical studies have suggested that they may result useful to treat diverse diseases, including those related with acute or chronic pain. The discovery of cannabinoid receptors, their endogenous ligands, and the machinery for the synthesis, transport, and degradation of these retrograde messengers, has equipped us with neurochemical tools for novel drug design. Agonist-activated cannabinoid receptors, modulate...

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The endocannabinoid system, cannabinoids, and pain.

Posted by Joe Pavlik on

Published: Rambam Maimonides Med J. 2013 Oct 29;4(4):e0022. doi: 10.5041/RMMJ.10129. eCollection 2013. The endocannabinoid system, cannabinoids, and pain. Fine PG, Rosenfeld MJ. Abstract The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act as ligands at endogenous cannabinoid receptors within the central nervous system (primarily but not exclusively CB 1 receptors) and in the periphery (primarily but not exclusively CB 2 receptors) are only partially elucidated, but they do exert an influence on nociception. Exogenous plant-based cannabinoids (phytocannabinoids) and chemically related compounds, like...

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