Alzheimer's Disease & CBD

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

Posted by Joe Pavlik on

Published: PLoS One. 2011; 6(12): e28668. Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement Giuseppe Esposito, Caterina Scuderi, Marta Valenza, Giuseppina Ines Togna, Valentina Latina, Daniele De Filippis, Mariateresa Cipriano, Maria Rosaria Carratù, Teresa Iuvone, and Luca Steardo Abstract Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to be involved in the etiology of pathological features of Alzheimer's disease (AD). Cannabidiol (CBD), a Cannabis derivative devoid of psychomimetic effects, has attracted much attention because of its promising neuroprotective properties in rat AD models, even though the mechanism responsible for such actions remains unknown. This study was aimed at...

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